Commitment to the Regulatory T Cell Lineage Requires CARMA1 in the Thymus but Not in the Periphery

Regulatory T (T(reg)) cells expressing forkhead box P3 (Foxp3) arise during thymic selection among thymocytes with modestly self-reactive T cell receptors. In vitro studies suggest Foxp3 can also be induced among peripheral CD4(+) T cells in a cytokine dependent manner. T(reg) cells of thymic or per...

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Autors principals: Barnes, Michael J, Krebs, Philippe, Harris, Nathaniel, Eidenschenk, Celine, Gonzalez-Quintial, Rosana, Arnold, Carrie N, Crozat, Karine, Sovath, Sosathya, Moresco, Eva Marie, Theofilopoulos, Argyrios N, Beutler, Bruce, Hoebe, Kasper
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2009
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2650725/
https://ncbi.nlm.nih.gov/pubmed/19260764
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.1000051
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