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Virologic Failure in Therapy-Naïve Subjects on Aplaviroc plus Lopinavir-Ritonavir: Detection of Aplaviroc Resistance Requires Clonal Analysis of Envelope

The CCR100136 (EPIC) study evaluated the antiviral activity of the novel CCR5 entry inhibitor aplaviroc in combination with lopinavir-ritonavir in drug-naïve human immunodeficiency virus type 1-infected subjects. Although the trial was stopped prematurely due to idiosyncratic hepatotoxicity, 11 subj...

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Main Authors: Kitrinos, Kathryn M., Amrine-Madsen, Heather, Irlbeck, David M., Word, J. Michael, Demarest, James F.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology (ASM) 2009
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2650553/
https://ncbi.nlm.nih.gov/pubmed/19075068
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01057-08
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