Human embryonic stem cell-derived motor neurons expressing SOD1 mutants exhibit typical signs of motor neuron degeneration linked to ALS

Human embryonic stem cell (hESC)-derived neurons have the potential to model neurodegenerative disorders. Here, we demonstrate the expression of a mutant gene, superoxide dismutase 1(SOD1), linked to familial amyotrophic lateral sclerosis (ALS) in hESC-derived motor neurons. Green fluorescent protei...

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Autors principals: Karumbayaram, Saravanan, Kelly, Theresa K., Paucar, Andres A., Roe, Anne J. T., Umbach, Joy A., Charles, Andrew, Goldman, Steven A., Kornblum, Harley I., Wiedau-Pazos, Martina
Format: Artigo
Idioma:Inglês
Publicat: The Company of Biologists Limited 2009
Matèries:
Research Report
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2650191/
https://ncbi.nlm.nih.gov/pubmed/19259395
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dmm.002113
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