A mouse forward genetics screen identifies LISTERIN as an E3 ubiquitin ligase involved in neurodegeneration

A mouse neurological mutant, lister, was identified through a genome-wide N-ethyl-N-nitrosourea (ENU) mutagenesis screen. Homozygous lister mice exhibit profound early-onset and progressive neurological and motor dysfunction. lister encodes a RING finger protein, LISTERIN, which functions as an E3 u...

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Xehetasun bibliografikoak
Egile Nagusiak: Chu, Jessie, Hong, Nancy A., Masuda, Claudio A., Jenkins, Brian V., Nelms, Keats A., Goodnow, Christopher C., Glynne, Richard J., Wu, Hua, Masliah, Eliezer, Joazeiro, Claudio A. P., Kay, Steve A.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: National Academy of Sciences 2009
Gaiak:
Biological Sciences
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC2650114/
https://ncbi.nlm.nih.gov/pubmed/19196968
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0812819106
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