Identifying the proteins to which small-molecule probes and drugs bind in cells

Most small-molecule probes and drugs alter cell circuitry by interacting with 1 or more proteins. A complete understanding of the interacting proteins and their associated protein complexes, whether the compounds are discovered by cell-based phenotypic or target-based screens, is extremely rare. Suc...

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מידע ביבליוגרפי
Main Authors: Ong, Shao-En, Schenone, Monica, Margolin, Adam A., Li, Xiaoyu, Do, Kathy, Doud, Mary K., Mani, D. R., Kuai, Letian, Wang, Xiang, Wood, John L., Tolliday, Nicola J., Koehler, Angela N., Marcaurelle, Lisa A., Golub, Todd R., Gould, Robert J., Schreiber, Stuart L., Carr, Steven A.
פורמט: Artigo
שפה:Inglês
יצא לאור: National Academy of Sciences 2009
נושאים:
Biological Sciences
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC2649954/
https://ncbi.nlm.nih.gov/pubmed/19255428
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0900191106
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