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Protein and nucleotide damage by glyoxal and methylglyoxal in physiological systems - role in ageing and disease

Glycation of proteins, nucleotides and basic phospholipids by glyoxal and methylglyoxal – physiological substrates of glyoxalase 1 - is potentially damaging to the proteome, genome and lipidome. Glyoxalase 1 suppresses glycation by these α-oxoaldehyde metabolites and thereby represents part of the e...

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Autore principale: Thornalley, Paul J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2008
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2649415/
https://ncbi.nlm.nih.gov/pubmed/18533367
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