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Defining the roles of Asn-128, Glu-129 and Phe-130 in loop A of the 5-HT(3) receptor
The ligand binding pocket of Cys-loop receptors consists of a number of binding loops termed A-F. Here we examine the 5-HT(3) receptor loop A residues Asn-128, Glu-129 and Phe-130 using modelling, mutagenesis, radioligand binding and functional studies on HEK 293 cells. Replacement of Asn-128 result...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2006
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2649376/ https://ncbi.nlm.nih.gov/pubmed/17060161 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/09687860600831539 |
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