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The Insulin/Akt Signaling Pathway Is Targeted by Intracellular β-Amyloid

Intraneuronal β-amyloid (Aβ(i)) accumulates early in Alzheimer's disease (AD) and inclusion body myositis. Several organelles, receptor molecules, homeostatic processes, and signal transduction components have been identified as sensitive to Aβ. Although prior studies implicate the insulin-PI3K...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Lee, Han-Kyu, Kumar, Pravir, Fu, Qinghao, Rosen, Kenneth M., Querfurth, Henry W.
Format: Artigo
Sprache:Inglês
Veröffentlicht: The American Society for Cell Biology 2009
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2649265/
https://ncbi.nlm.nih.gov/pubmed/19144826
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E08-07-0777
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