(V600E)BRAF is associated with disabled feedback inhibition of RAF–MEK signaling and elevated transcriptional output of the pathway

Tumors with mutant BRAF and those with receptor tyrosine kinase (RTK) activation have similar levels of phosphorylated ERK, but only the former depend on ERK signaling for proliferation. The mitogen-activated protein kinase, extracellular signal-regulated kinase kinase (MEK)/ERK-dependent transcript...

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Detaylı Bibliyografya
Asıl Yazarlar: Pratilas, Christine A., Taylor, Barry S., Ye, Qing, Viale, Agnes, Sander, Chris, Solit, David B., Rosen, Neal
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: National Academy of Sciences 2009
Konular:
Biological Sciences
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2649208/
https://ncbi.nlm.nih.gov/pubmed/19251651
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0900780106
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