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Solution NMR Structure of the C-terminal EF-hand Domain of Human Cardiac Sodium Channel Na(V)1.5

The voltage-gated sodium channel Na(V)1.5 is responsible for the initial upstroke of the action potential in cardiac tissue. Levels of intracellular calcium modulate inactivation gating of Na(V)1.5, in part through a C-terminal EF-hand calcium binding domain. The significance of this structure is un...

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Main Authors: Chagot, Benjamin, Potet, Franck, Balser, Jeffrey R., Chazin, Walter J.
格式: Artigo
語言:Inglês
出版: American Society for Biochemistry and Molecular Biology 2009
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2649110/
https://ncbi.nlm.nih.gov/pubmed/19074138
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M807747200
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