Growth Hormone Inhibition of Glucose Uptake in Adipocytes Occurs without Affecting GLUT4 Translocation through an Insulin Receptor Substrate-2-Phosphatidylinositol 3-Kinase-dependent Pathway

Growth hormone (GH) pretreatment of 3T3-L1 adipocytes resulted in a concentration- and time-dependent inhibition of insulin-stimulated glucose uptake. Surprisingly, this occurred without significant effect on insulin-stimulated glucose transporter (GLUT) 4 translocation or fusion with the plasma mem...

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Bibliographische Detailangaben
Hauptverfasser: Sasaki-Suzuki, Naoko, Arai, Kiyoshi, Ogata, Tomomi, Kasahara, Kouhei, Sakoda, Hideyuki, Chida, Kazuhiro, Asano, Tomoichiro, Pessin, Jeffrey E., Hakuno, Fumihiko, Takahashi, Shin-Ichiro
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2009
Schlagworte:
Mechanisms of Signal Transduction
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2649092/
https://ncbi.nlm.nih.gov/pubmed/19122000
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M808282200
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