Cleavage of the IPS-1/Cardif/MAVS/VISA does not inhibit T cell-mediated elimination of hepatitis C virus non-structural 3/4A-expressing hepatocytes

BACKGROUND: Hepatitis C virus (HCV) effectively establishes persistent infection in human livers. The non-structural (NS) 3/4A complex participates in this process by cleavage of interferon β (IFNβ) promoter stimulator-1 (IPS-1; also termed Cardif/MAVS/VISA), which inhibits responses to double stran...

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Main Authors: Ahlén, G, Derk, E, Weiland, M, Jiao, J, Rahbin, N, Aleman, S, Peterson, D L, Pokrovskaja, K, Grandér, D, Frelin, L, Sällberg, M
Format: Artigo
Language:Inglês
Published: BMJ Publishing Group 2009
Subjects:
Hepatology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2648966/
https://ncbi.nlm.nih.gov/pubmed/18689426
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/gut.2007.147264
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