Dissociation of a MAVS/IPS-1/VISA/Cardif-IKKɛ Molecular Complex from the Mitochondrial Outer Membrane by Hepatitis C Virus NS3-4A Proteolytic Cleavage

Intracellular RNA virus infection is detected by the cytoplasmic RNA helicase RIG-I that plays an essential role in signaling to the host antiviral response. Recently, the adapter molecule that links RIG-I sensing of incoming viral RNA to downstream signaling and gene activation events was character...

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Bibliographische Detailangaben
Hauptverfasser: Lin, Rongtuan, Lacoste, Judith, Nakhaei, Peyman, Sun, Qiang, Yang, Long, Paz, Suzanne, Wilkinson, Peter, Julkunen, Ilkka, Vitour, Damien, Meurs, Eliane, Hiscott, John
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2006
Schlagworte:
Pathogenesis and Immunity
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1472616/
https://ncbi.nlm.nih.gov/pubmed/16731946
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02495-05
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