Hepatitis C virus NS2 and NS3/4A proteins are potent inhibitors of host cell cytokine/chemokine gene expression

BACKGROUND: Hepatitis C virus (HCV) encodes several proteins that interfere with the host cell antiviral response. Previously, the serine protease NS3/4A was shown to inhibit IFN-β gene expression by blocking dsRNA-activated retinoic acid-inducible gene I (RIG-I) and Toll-like receptor 3 (TLR3)-medi...

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Detalhes bibliográficos
Main Authors: Kaukinen, Pasi, Sillanpää, Maarit, Kotenko, Sergei, Lin, Rongtuan, Hiscott, John, Melén, Krister, Julkunen, Ilkka
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2006
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1569370/
https://ncbi.nlm.nih.gov/pubmed/16945160
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1743-422X-3-66
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