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Ceramide synthase 6 modulates TRAIL sensitivity and nuclear translocation of active caspase 3 in colon cancer cells
We have previously shown that the death receptor ligand TRAIL induces an increase in intracellular C(16)-ceramide in sensitive SW480 but not in resistant SW620 cells. Resistance in SW620 cells was overcome by exogenous ceramide leading us to propose that defective ceramide signaling contributes to T...
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| Autors principals: | , , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2009
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2648838/ https://ncbi.nlm.nih.gov/pubmed/19137010 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2008.468 |
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