A computational analysis of SARS cysteine proteinase-octapeptide substrate interaction: implication for structure and active site binding mechanism

BACKGROUND: SARS coronavirus main proteinase (SARS CoVMpro) is an important enzyme for the replication of Severe Acute Respiratory Syndrome virus. The active site region of SARS CoVMpro is divided into 8 subsites. Understanding the binding mode of SARS CoVMpro with a specific substrate is useful and...

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Bibliographic Details
Main Authors: Phakthanakanok, Krongsakda, Ratanakhanokchai, Khanok, Kyu, Khin Lay, Sompornpisut, Pornthep, Watts, Aaron, Pinitglang, Surapong
Format: Artigo
Language:Inglês
Published: BioMed Central 2009
Subjects:
Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2648740/
https://ncbi.nlm.nih.gov/pubmed/19208150
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2105-10-S1-S48
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