HLA-B57/B*5801 Human Immunodeficiency Virus Type 1 Elite Controllers Select for Rare Gag Variants Associated with Reduced Viral Replication Capacity and Strong Cytotoxic T-Lymphotye Recognition

Human immunodeficiency virus type 1 (HIV-1) elite controllers (EC) maintain viremia below the limit of commercial assay detection (<50 RNA copies/ml) in the absence of antiviral therapy, but the mechanisms of control remain unclear. HLA-B57 and the closely related allele B*5801 are particularly a...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Miura, Toshiyuki, Brockman, Mark A., Schneidewind, Arne, Lobritz, Michael, Pereyra, Florencia, Rathod, Almas, Block, Brian L., Brumme, Zabrina L., Brumme, Chanson J., Baker, Brett, Rothchild, Alissa C., Li, Bin, Trocha, Alicja, Cutrell, Emily, Frahm, Nicole, Brander, Christian, Toth, Ildiko, Arts, Eric J., Allen, Todd M., Walker, Bruce D.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Microbiology (ASM) 2009
Pynciau:
Pathogenesis and Immunity
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC2648254/
https://ncbi.nlm.nih.gov/pubmed/19116253
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02265-08
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