HLA-B57/B*5801 Human Immunodeficiency Virus Type 1 Elite Controllers Select for Rare Gag Variants Associated with Reduced Viral Replication Capacity and Strong Cytotoxic T-Lymphotye Recognition

Human immunodeficiency virus type 1 (HIV-1) elite controllers (EC) maintain viremia below the limit of commercial assay detection (<50 RNA copies/ml) in the absence of antiviral therapy, but the mechanisms of control remain unclear. HLA-B57 and the closely related allele B*5801 are particularly a...

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Détails bibliographiques
Auteurs principaux: Miura, Toshiyuki, Brockman, Mark A., Schneidewind, Arne, Lobritz, Michael, Pereyra, Florencia, Rathod, Almas, Block, Brian L., Brumme, Zabrina L., Brumme, Chanson J., Baker, Brett, Rothchild, Alissa C., Li, Bin, Trocha, Alicja, Cutrell, Emily, Frahm, Nicole, Brander, Christian, Toth, Ildiko, Arts, Eric J., Allen, Todd M., Walker, Bruce D.
Format: Artigo
Langue:Inglês
Publié: American Society for Microbiology (ASM) 2009
Sujets:
Pathogenesis and Immunity
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2648254/
https://ncbi.nlm.nih.gov/pubmed/19116253
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02265-08
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