Lack of a significant impact of Gag-Protease-mediated HIV-1 replication capacity on clinical parameters in treatment-naive Japanese individuals

BACKGROUND: HLA class I-associated escape mutations in HIV-1 Gag can reduce viral replication, suggesting that associated fitness costs could impact HIV-1 disease progression. Previous studies in North American and African cohorts have reported reduced Gag-Protease mediated viral replication capacit...

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Enregistré dans:
Détails bibliographiques
Publié dans:Retrovirology
Auteurs principaux: Sakai, Keiko, Chikata, Takayuki, Brumme, Zabrina L., Brumme, Chanson J., Gatanag, Hiroyuki, Oka, Shinichi, Takiguchi, Masafumi
Format: Artigo
Langue:Inglês
Publié: BioMed Central 2015
Sujets:
Research
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4653850/
https://ncbi.nlm.nih.gov/pubmed/26585907
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12977-015-0223-z
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