IBD-Associated TL1A Gene (TNFSF15) Haplotypes Determine Increased Expression of TL1A Protein

BACKGROUND: The recently identified member of the TNF superfamily TL1A (TNFSF15) increases IFN-γ production by T cells in peripheral and mucosal CCR9+ T cells. TL1A and its receptor DR3 are up-regulated during chronic intestinal inflammation in ulcerative colitis and Crohn's disease (CD). TL1A...

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Main Authors: Michelsen, Kathrin S., Thomas, Lisa S., Taylor, Kent D., Yu, Qi T., Mei, Ling, Landers, Carol J., Derkowski, Carrie, McGovern, Dermot P. B., Rotter, Jerome I., Targan, Stephan R.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2009
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2648040/
https://ncbi.nlm.nih.gov/pubmed/19262684
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0004719
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