Recurrent RECQL4 Imbalance and Increased Gene Expression Levels Are Associated with Structural Chromosomal Instability in Sporadic Osteosarcoma

Osteosarcoma (OS) is an aggressive bone tumor with complex abnormal karyotypes and a highly unstable genome, exhibiting both numerical- and structural-chromosomal instability (N- and S-CIN). Chromosomal rearrangements and genomic imbalances affecting 8q24 are frequent in OS. RECQL4 gene maps to this...

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Hlavní autoři: Maire, Georges, Yoshimoto, Maisa, Chilton-MacNeill, Susan, Thorner, Paul S, Zielenska, Maria, Squire, Jeremy A
Médium: Artigo
Jazyk:Inglês
Vydáno: Neoplasia Press Inc. 2009
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2647728/
https://ncbi.nlm.nih.gov/pubmed/19242607
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