RANK is the intrinsic hematopoietic cell surface receptor that controls osteoclastogenesis and regulation of bone mass and calcium metabolism

We have generated RANK (receptor activator of NF-κB) nullizygous mice to determine the molecular genetic interactions between osteoprotegerin, osteoprotegerin ligand, and RANK during bone resorption and remodeling processes. RANK(−/−) mice lack osteoclasts and have a profound defect in bone resorpti...

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Auteurs principaux: Li, Ji, Sarosi, Ildiko, Yan, Xiao-Qiang, Morony, Sean, Capparelli, Casey, Tan, Hong-Lin, McCabe, Susan, Elliott, Robin, Scully, Sheila, Van, Gwyneth, Kaufman, Stephen, Juan, Shao-Chieh, Sun, Yu, Tarpley, John, Martin, Laura, Christensen, Kathleen, McCabe, James, Kostenuik, Paul, Hsu, Hailing, Fletcher, Frederick, Dunstan, Colin R., Lacey, David L., Boyle, William J.
Format: Artigo
Langue:Inglês
Publié: The National Academy of Sciences 2000
Sujets:
Biological Sciences
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC26475/
https://ncbi.nlm.nih.gov/pubmed/10677500
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