Mechanism of the Quorum-Quenching Lactonase (AiiA) from Bacillus thuringiensis. 2. Substrate Modeling and Active Site Mutations

[Image: see text] The N-acyl-l-homoserine lactone hydrolases (AHL lactonases) have attracted considerable attention because of their ability to quench AHL-mediated quorum-sensing pathways in Gram-negative bacteria and because of their relation to other enzymes in the metallo-β-lactamase superfamily....

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Bibliographic Details
Main Authors: Momb, Jessica, Wang, Canhui, Liu, Dali, Thomas, Pei W., Petsko, Gregory A., Guo, Hua, Ringe, Dagmar, Fast, Walter
Format: Artigo
Language:Inglês
Published: American Chemical Society 2008
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2646874/
https://ncbi.nlm.nih.gov/pubmed/18627130
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi8003704
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