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Molecular Basis for the Structural Instability of Human DJ-1 Induced by the L166P Mutation Associated with Parkinson’s Disease
DJ-1 is a dimeric protein of unknown function in vivo. A mutation in the human DJ-1 gene causing substitution of proline for leucine at residue 166 (L166P) has been linked to early-onset Parkinson’s disease. Lack of structural stability has precluded experimental determination of atomic-resolution s...
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2008
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2646841/ https://ncbi.nlm.nih.gov/pubmed/18707128 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi800677k |
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