Analysis of Ret knockin mice reveals a critical role for IKKs, but not PI 3-K, in neurotrophic factor-induced survival of sympathetic neurons

We analyzed the survival responses and downstream signaling elicited by GDNF on sympathetic neurons from different Ret knockin mice. Lack of tyrosine 1062, a multidocking site in Ret, completely prevented GDNF-mediated survival. Importantly lack of tyrosine 981, although abrogating Akt phosphorylati...

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Detalhes bibliográficos
Main Authors: Encinas, Mario, Rozen, Esteban J., Dolcet, Xavier, Jain, Sanjay, Comella, Joan X., Milbrandt, Jeffrey, Johnson, Eugene M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2646785/
https://ncbi.nlm.nih.gov/pubmed/18497757
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2008.76
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