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Directed evolution of adeno-associated virus to an infectious respiratory virus
Respiratory viruses evolve to maintain infectivity levels that permit spread yet prevent host and virus extinction, resulting in surprisingly low infection rates. Respiratory viruses harnessed as gene therapy vectors have illustrated this limitation. We used directed evolution in an organotypic huma...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2646629/ https://ncbi.nlm.nih.gov/pubmed/19237554 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0813365106 |
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