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Regulated Proteolysis of DNA Polymerase Eta During the DNA Damage Response in C. elegans
Both the POLH-1 (pol eta) trans-lesion synthesis DNA polymerase and the GEI-17 SUMO E3 ligase are essential for the efficient replication of damaged chromosomes in C. elegans embryos. Here, we study how POLH-1 is regulated during a DNA damage response in these embryos. We report that DNA damage trig...
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| Autori principali: | , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2008
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2646262/ https://ncbi.nlm.nih.gov/pubmed/19111656 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2008.11.016 |
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