Primary Defects in β-Cell Function Further Exacerbated by Worsening of Insulin Resistance Mark the Development of Impaired Glucose Tolerance in Obese Adolescents

OBJECTIVE—Impaired glucose tolerance (IGT) is a pre-diabetic state of increasing prevalence among obese adolescents. The purpose of this study was to determine the natural history of progression from normal glucose tolerance (NGT) to IGT in obese adolescents. RESEARCH DESIGN AND METHODS—We determine...

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Detalhes bibliográficos
Main Authors: Cali, Anna M.G., Man, Chiara Dalla, Cobelli, Claudio, Dziura, James, Seyal, Aisha, Shaw, Melissa, Allen, Karin, Chen, Shu, Caprio, Sonia
Formato: Artigo
Idioma:Inglês
Publicado em: American Diabetes Association 2009
Assuntos:
Pathophysiology/Complications
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2646028/
https://ncbi.nlm.nih.gov/pubmed/19106382
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/dc08-1274
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