Urine Metabolites Reflect Time-Dependent Effects of Cyclosporine and Sirolimus on Rat Kidney Function

BACKGROUND: The clinical use of the immunosuppressant calcineurin inhibitor cyclosporine is limited by its nephrotoxicity. This is enhanced when combined with the immunosuppressive mTOR inhibitor sirolimus. Nephrotoxicity of both drugs is not yet fully understood. METHODS: The goal was to gain more...

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Autori principali: Klawitter, Jost, Bendrick-Peart, Jamie, Rudolph, Birgit, Beckey, Virginia, Klawitter, Jelena, Haschke, Manuel, Rivard, Christopher, Chan, Laurence, Leibfritz, Dieter, Christians, Uwe, Schmitz, Volker
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2009
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2646011/
https://ncbi.nlm.nih.gov/pubmed/19099400
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/tx800253x
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