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Ligand-Induced Conformational Heterogeneity of Cytochrome P450 CYP119 Identified by 2D NMR Spectroscopy with the Unnatural Amino Acid (13)C-p-Methoxyphenylalanine
Conformational dynamics are thought to play an important role in ligand binding and catalysis by cytochrome P450 enzymes but few techniques exist to examine them in molecular detail. Using a unique isotopic labeling strategy, we have site specifically inserted a (13)C-labeled unnatural amino acid re...
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| Autors principals: | , , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2008
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2645923/ https://ncbi.nlm.nih.gov/pubmed/18998650 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja8071463 |
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