Naturally occurring dominant resistance mutations to HCV protease and polymerase inhibitors in treatment-naïve patients

Resistance mutations to HCV NS3 protease inhibitors in <1% of the viral quasispecies may still allow >1000-fold viral load reductions upon treatment, consistent with their reported reduced replicative fitness in vitro. Recently, however, an R155K protease mutation was reported as the dominant...

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Main Authors: Kuntzen, Thomas, Timm, Joerg, Berical, Andrew, Lennon, Niall, Berlin, Aaron M., Young, Sarah K., Lee, Bongshin, Heckerman, David, Carlson, Jonathan, Reyor, Laura L., Kleyman, Marianna, McMahon, Cory M., Birch, Christopher, Wiesch, Julian Schulze zur, Ledlie, Timothy, Koehrsen, Michael, Kodira, Chinnappa, Roberts, Andrew D., Lauer, Georg M., Rosen, Hugo R., Bihl, Florian, Cerny, Andreas, Spengler, Ulrich, Liu, Zhimin, Kim, Arthur Y., Xing, Yanming, Schneidewind, Arne, Madey, Margaret A., Fleckenstein, Jaquelyn F., Park, Vicki M., Galagan, James E., Nusbaum, Chad, Walker, Bruce D., Lake-Bakaar, Gerond V., Daar, Eric S., Jacobson, Ira M., Gomperts, Edward D., Edlin, Brian R., Donfield, Sharyne M., Chung, Raymond T., Talal, Andrew H., Marion, Tony, Birren, Bruce W., Henn, Matthew R., Allen, Todd M.
格式: Artigo
語言:Inglês
出版: 2008
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2645896/
https://ncbi.nlm.nih.gov/pubmed/19026009
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.22549
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