A DNA Polymerase-α·Primase Cofactor with Homology to Replication Protein A-32 Regulates DNA Replication in Mammalian Cells

α-Accessory factor (AAF) stimulates the activity of DNA polymerase-α·primase, the only enzyme known to initiate DNA replication in eukaryotic cells (Goulian, M., Heard, C. J., and Grimm, S. L. (1990) J. Biol. Chem.265 ,13221 -132302165497). We purified the AAF heterodimer composed of 44- and 132-kDa...

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Detalhes bibliográficos
Main Authors: Casteel, Darren E., Zhuang, Shunhui, Zeng, Ying, Perrino, Fred W., Boss, Gerry R., Goulian, Mehran, Pilz, Renate B.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2009
Assuntos:
DNA: Replication, Repair, Recombination, and Chromosome Dynamics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2645831/
https://ncbi.nlm.nih.gov/pubmed/19119139
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M807593200
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