Foxp3 Processing by Proprotein Convertases and Control of Regulatory T Cell Function

Foxp3 is a 47-kDa transcription factor central to regulatory T cell (Treg) function. The importance of Foxp3(+) Tregs in controlling self-reactive T cells and preventing autoimmunity is well established. Our analysis of Foxp3 expression in natural Tregs led to identification of a shorter 41-kDa Foxp...

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Bibliographische Detailangaben
Hauptverfasser: de Zoeten, Edwin F., Lee, Iris, Wang, Liqing, Chen, Chunxia, Ge, Guanghui, Wells, Andrew D., Hancock, Wayne W., Özkaynak, Engin
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2009
Schlagworte:
Protein Synthesis, Post-Translational Modification, and Degradation
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2645825/
https://ncbi.nlm.nih.gov/pubmed/19117830
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M807322200
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