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Zinc Finger Transcription Factor INSM1 Interrupts Cyclin D1 and CDK4 Binding and Induces Cell Cycle Arrest

INSM1 is a zinc finger transcription factor that plays an important role in pancreatic β-cell development. To further evaluate its role in cell fate determination, we investigated INSM1 effects on cell cycle function. The cyclin box of cyclin D1 is essential for INSM1 binding. Competitive pull-down...

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מידע ביבליוגרפי
Main Authors: Zhang, Tao, Liu, Wei-Dong, Saunee, Nicolle A., Breslin, Mary B., Lan, Michael S.
פורמט: Artigo
שפה:Inglês
יצא לאור: American Society for Biochemistry and Molecular Biology 2009
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC2645817/
https://ncbi.nlm.nih.gov/pubmed/19124461
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M808843200
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