Zinc Protoporphyrin Regulates Cyclin D1 Expression Independent of Heme Oxygenase Inhibition

Zinc protoporphyrin IX (ZnPP), an endogenous heme analogue that inhibits heme oxygenase (HO) activity, represses tumor growth. It can also translocate into the nucleus and up-regulate heme oxygenase 1 (HMOX1) gene expression. Here, we demonstrate that tumor cell proliferation was inhibited by ZnPP,...

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Bibliografiske detaljer
Main Authors: La, Ping, Fernando, Amal P., Wang, Zhi, Salahudeen, Ameen, Yang, Guang, Lin, Qing, Wright, Clyde J., Dennery, Phyllis A.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2009
Fag:
Molecular Basis of Cell and Developmental Biology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2794746/
https://ncbi.nlm.nih.gov/pubmed/19850937
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.031641
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