Rapid Regulatory T-Cell Response Prevents Cytokine Storm in CD28 Superagonist Treated Mice

Superagonistic CD28-specific monoclonal antibodies (CD28SA) are highly effective activators of regulatory T-cells (Treg cells) in rats, but a first-in-man trial of the human CD28SA TGN1412 resulted in an unexpected cytokine release syndrome. Using a novel mouse anti-mouse CD28SA, we re-investigate t...

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Detalhes bibliográficos
Main Authors: Gogishvili, Tea, Langenhorst, Daniela, Lühder, Fred, Elias, Fernando, Elflein, Karin, Dennehy, Kevin M., Gold, Ralf, Hünig, Thomas
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2009
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2645706/
https://ncbi.nlm.nih.gov/pubmed/19247496
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0004643
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