Topological Requirements and Signaling Properties of T Cell–activating, Anti-CD28 Antibody Superagonists

Full activation of naive T cells requires both engagement of the T cell antigen receptor (TCR; signal 1) and costimulatory signaling by CD28 (signal 2). We previously identified two types of rat CD28-specific monoclonal antibodies (mAbs): “conventional,” TCR signaling–dependent costimulatory mAbs an...

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Main Authors: Lühder, Fred, Huang, Yun, Dennehy, Kevin M., Guntermann, Christine, Müller, Ingrid, Winkler, Erna, Kerkau, Thomas, Ikemizu, Shinji, Davis, Simon J., Hanke, Thomas, Hünig, Thomas
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2003
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2193880/
https://ncbi.nlm.nih.gov/pubmed/12707299
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20021024
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