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Topological Requirements and Signaling Properties of T Cell–activating, Anti-CD28 Antibody Superagonists
Full activation of naive T cells requires both engagement of the T cell antigen receptor (TCR; signal 1) and costimulatory signaling by CD28 (signal 2). We previously identified two types of rat CD28-specific monoclonal antibodies (mAbs): “conventional,” TCR signaling–dependent costimulatory mAbs an...
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| Main Authors: | , , , , , , , , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
The Rockefeller University Press
2003
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2193880/ https://ncbi.nlm.nih.gov/pubmed/12707299 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20021024 |
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