Selective targeting of regulatory T cells with CD28 superagonists allows effective therapy of experimental autoimmune encephalomyelitis

CD4(+)CD25(+) regulatory T cells (T reg cells) play a key role in controlling autoimmunity and inflammation. Therefore, therapeutic agents that are capable of elevating numbers or increasing effector functions of this T cell subset are highly desirable. In a previous report we showed that a superago...

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Main Authors: Beyersdorf, Niklas, Gaupp, Stefanie, Balbach, Karen, Schmidt, Jens, Toyka, Klaus V., Lin, Chia-Huey, Hanke, Thomas, Hünig, Thomas, Kerkau, Thomas, Gold, Ralf
Format: Artigo
Language:Inglês
Published: The Rockefeller University Press 2005
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2213080/
https://ncbi.nlm.nih.gov/pubmed/16061730
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20051060
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