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Micro-Environmental Mechanical Stress Controls Tumor Spheroid Size and Morphology by Suppressing Proliferation and Inducing Apoptosis in Cancer Cells

BACKGROUND: Compressive mechanical stress produced during growth in a confining matrix limits the size of tumor spheroids, but little is known about the dynamics of stress accumulation, how the stress affects cancer cell phenotype, or the molecular pathways involved. METHODOLOGY/PRINCIPAL FINDINGS:...

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Main Authors: Cheng, Gang, Tse, Janet, Jain, Rakesh K., Munn, Lance L.
פורמט: Artigo
שפה:Inglês
יצא לאור: Public Library of Science 2009
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC2645686/
https://ncbi.nlm.nih.gov/pubmed/19247489
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0004632
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