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Solid stress facilitates spheroid formation: potential involvement of hyaluronan

When neoplastic cells grow in confined spaces in vivo, they exert a finite force on the surrounding tissue resulting in the generation of solid stress. By growing multicellular spheroids in agarose gels of defined mechanical properties, we have recently shown that solid stress inhibits the growth of...

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Detalhes bibliográficos
Main Authors: Koike, C, McKee, T D, Pluen, A, Ramanujan, S, Burton, K, Munn, L L, Boucher, Y, Jain, R K
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2002
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2364140/
https://ncbi.nlm.nih.gov/pubmed/11953828
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6600158
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