Solid stress facilitates spheroid formation: potential involvement of hyaluronan

When neoplastic cells grow in confined spaces in vivo, they exert a finite force on the surrounding tissue resulting in the generation of solid stress. By growing multicellular spheroids in agarose gels of defined mechanical properties, we have recently shown that solid stress inhibits the growth of...

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Bibliografiske detaljer
Main Authors: Koike, C, McKee, T D, Pluen, A, Ramanujan, S, Burton, K, Munn, L L, Boucher, Y, Jain, R K
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2002
Fag:
Experimental Therapeutics
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2364140/
https://ncbi.nlm.nih.gov/pubmed/11953828
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6600158
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