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Energy landscape along an enzymatic reaction trajectory: hinges or cracks?

Are the most dynamically flexible regions around the equilibrium structure of an enzyme the same regions involved in the transition state for rate limiting processes involved in the enzymatic reaction? Kern and-coworkers (Wolf-Watzet al., 2004; Henzler-Wildman et al., 2007a, 2007b) have shown that i...

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Bibliografske podrobnosti
Main Authors: Whitford, Paul Charles, Onuchic, José Nelson, Wolynes, Peter Guy
Format: Artigo
Jezik:Inglês
Izdano: HFSP Publishing 2008
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2645576/
https://ncbi.nlm.nih.gov/pubmed/19404472
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2976/1.2894846
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