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Correcting Estimators of θ and Tajima's D for Ascertainment Biases Caused by the Single-Nucleotide Polymorphism Discovery Process

Most single-nucleotide polymorphism (SNP) data suffer from an ascertainment bias caused by the process of SNP discovery followed by SNP genotyping. The final genotyped data are biased toward an excess of common alleles compared to directly sequenced data, making standard genetic methods of analysis...

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Bibliografske podrobnosti
Main Authors: Ramírez-Soriano, Anna, Nielsen, Rasmus
Format: Artigo
Jezik:Inglês
Izdano: Genetics Society of America 2009
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2644958/
https://ncbi.nlm.nih.gov/pubmed/19087964
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1534/genetics.108.094060
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