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Cathepsin D expression level affects alpha-synuclein processing, aggregation, and toxicity in vivo
BACKGROUND: Elevated SNCA gene expression and intracellular accumulation of the encoded α-synuclein (aSyn) protein are associated with the development of Parkinson disease (PD). To date, few enzymes have been examined for their ability to degrade aSyn. Here, we explore the effects of CTSD gene expre...
Αποθηκεύτηκε σε:
| Κύριοι συγγραφείς: | , , , , , , , , , , , , |
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| Μορφή: | Artigo |
| Γλώσσα: | Inglês |
| Έκδοση: |
BioMed Central
2009
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| Θέματα: | |
| Διαθέσιμο Online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2644690/ https://ncbi.nlm.nih.gov/pubmed/19203374 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1756-6606-2-5 |
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