Calpain-Cleavage of α-Synuclein : Connecting Proteolytic Processing to Disease-Linked Aggregation

Parkinson’s disease (PD) and dementia with Lewy bodies (DLB) are both characterized pathologically by the presence of neuronal inclusions termed Lewy bodies (LBs). A common feature found in LBs are aggregates of α-synuclein (α-Syn), and although it is now recognized that α-Syn is the major building...

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Hlavní autoři: Dufty, Brian M., Warner, Lisa R., Hou, Sheng T., Jiang, Susan X., Gomez-Isla, Teresa, Leenhouts, Kristen M., Oxford, Julia T., Feany, Mel B., Masliah, Eliezer, Rohn, Troy T.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Investigative Pathology 2007
Témata:
Regular Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1854966/
https://ncbi.nlm.nih.gov/pubmed/17456777
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2007.061232
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