Cathepsin D expression level affects alpha-synuclein processing, aggregation, and toxicity in vivo

BACKGROUND: Elevated SNCA gene expression and intracellular accumulation of the encoded α-synuclein (aSyn) protein are associated with the development of Parkinson disease (PD). To date, few enzymes have been examined for their ability to degrade aSyn. Here, we explore the effects of CTSD gene expre...

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Detalhes bibliográficos
Main Authors: Cullen, Valerie, Lindfors, Maria, Ng, Juliana, Paetau, Anders, Swinton, Erika, Kolodziej, Piotr, Boston, Heather, Saftig, Paul, Woulfe, John, Feany, Mel B, Myllykangas, Liisa, Schlossmacher, Michael G, Tyynelä, Jaana
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2009
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2644690/
https://ncbi.nlm.nih.gov/pubmed/19203374
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1756-6606-2-5
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