K(+)-dependent paradoxical membrane depolarization and Na(+) overload, major and reversible contributors to weakness by ion channel leaks

Normal resting potential (P1) of myofibers follows the Nernst equation, exhibiting about −85 mV at a normal extracellular K(+) concentration ([K(+)](o)) of 4 mM. Hyperpolarization occurs with decreased [K(+)](o), although at [K(+)](o) < 1.0 mM, myofibers paradoxically depolarize to a second stabl...

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Autores principales: Jurkat-Rott, Karin, Weber, Marc-André, Fauler, Michael, Guo, Xiu-Hai, Holzherr, Boris D., Paczulla, Agathe, Nordsborg, Nikolai, Joechle, Wolfgang, Lehmann-Horn, Frank
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 2009
Materias:
Biological Sciences
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2644652/
https://ncbi.nlm.nih.gov/pubmed/19225109
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0811277106
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