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A gating model for wildtype and R1448H Nav1.4 channels in paramyotonia

We studied the consequences of the Nav1.4 mutation R1448H that is situated in the fourth voltage sensor of the channel and causes paramyotonia, a cold-induced myotonia followed by weakness. Previous work showed that the mutation uncouples inactivation from activation. We measured whole-cell Na(+) cu...

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Xehetasun bibliografikoak
Egile Nagusiak: HOLZHERR, BORIS, LEHMANN-HORN, FRANK, KUZMENKINA, ELZA, FAN, CHUNXIANG, JURKAT-ROTT, KARIN
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Pacini Editore SpA 2014
Gaiak:
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4021628/
https://ncbi.nlm.nih.gov/pubmed/24843232
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