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K(+)-dependent paradoxical membrane depolarization and Na(+) overload, major and reversible contributors to weakness by ion channel leaks
Normal resting potential (P1) of myofibers follows the Nernst equation, exhibiting about −85 mV at a normal extracellular K(+) concentration ([K(+)](o)) of 4 mM. Hyperpolarization occurs with decreased [K(+)](o), although at [K(+)](o) < 1.0 mM, myofibers paradoxically depolarize to a second stabl...
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| Main Authors: | , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2644652/ https://ncbi.nlm.nih.gov/pubmed/19225109 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0811277106 |
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