Activated TNF-α/NF-κB signaling via down-regulation of Fas-associated factor 1 in asbestos-induced mesotheliomas from Arf knockout mice

The human CDKN2A locus encodes 2 distinct proteins, p16(INK4A) and p14(ARF) [mouse p19(Arf)], designated INK4A (inhibitor of cyclin dependent kinase 4) and ARF (alternative reading frame) here, that are translated from alternatively spliced mRNAs. Human ARF is implicated as a tumor suppressor gene,...

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Detalhes bibliográficos
Main Authors: Altomare, Deborah A., Menges, Craig W., Pei, Jianming, Zhang, Lili, Skele-Stump, Kristine L., Carbone, Michele, Kane, Agnes B., Testa, Joseph R.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2009
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2644256/
https://ncbi.nlm.nih.gov/pubmed/19223589
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0808816106
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